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Updating p300 an integrative theory of p3a and p3b

updating p300 an integrative theory of p3a and p3b-19

The signs and symptoms of restless legs syndrome are decreased by movement, especially by walking.

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A superimposition effect of depression and anxiety was identified with (1) aggravated hypo-function of the right-lateralized dorsal attention and salience networks and (2) complicated anxiety-related hyper-function of the left-lateralized ventral attention and salience networks..The P3b can also be used to measure how demanding a task is on cognitive workload.found that ERP responses to visual stimuli differed depending on whether the stimuli had meaning or not.Loud tones occurred with a probability of .9, .5, or .1, while the soft tones occurred with complementary probability.In addition, subjects completed blocks of stimuli under instruction to count the number of loud tones, count the number of soft tones, or ignore the tones and quietly read.The P3a has been associated with brain activity related to the engagement of attention (especially orienting and involuntary shifts to changes in the environment) and the processing of novelty.

In 1975 Squires and colleagues conducted a study attempting to resolve some of the questions surrounding what neural process the P300 reflects.

Event-related brain potentials (ERPs) were used to assess patients with restless legs syndrome. Normative variation of P3a and P3b from a large sample: gender, topography, and response time.

ERPs enable the direct evaluation of CNS neuroelectric activity during processing of stimulus information.

estless legs syndrome may be a condition of impaired CNS dopamine function.

Dopamine deficiency is associated with bradykinesia and impaired attention (e.g., Parkinson's disease and attention deficit disorder), and dopamine restoration or excess (e.g., treatment of patients with Parkinson's disease with L-3,4-dihydroxyphenlyalanine [L-dopa] and of patients with attention deficit disorder with amphetamine) is associated with normal or excessive movement and with improved attention.

For P3b, depressed patients showed decreased right-lateralized activity in the precentral sulcus (Pr CS) and posterior parietal cortex (PPC).